Wednesday, 10 November 2004 - 4:40 PM
10

This presentation is part of: Medicinal Chemistry I (General Session)

DEOXY ANALOGS OF CP-47,497 AND CP-55,940 AS POTENTIAL CB2 SELECTIVE LIGANDS

Alicia L. S. Thompson1, John W. Huffman1, Jenny L. Wiley2, and Billy R. Martin2. (1) Clemson University, Clemson, SC, (2) Virginia Commonwealth University, Richmond, VA

Although the benzopyran ring system of THC was considered essential for cannabinoid activity, bicyclic non-traditional cannabinoids such as CP-47,497 and CP-55,940 were developed by Pfizer. These compounds have high affinity for the CB1 and CB2 receptors and are potent cannabinoids in vivo.

Traditional 1-deoxy-3-(1',1'-dimethylalkyl)-Δ8-THC analogues have been synthesized and are highly selective CB2 agonists.

In an effort to develop new CB2 selective ligands, the syntheses of several series of deoxy analogs of the Pfizer bicyclic non-traditional cannabinoids were initiated. The syntheses and receptor affinities of these CP-47,497 and CP-55,940 analogs will be discussed.


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