Polymeric nanoparticles and functionalized carbon nanotubes bearing multiple carbohydrate ligands were synthesized and characterized. Their cell adhesion interactions were investigated. Specifically, these sugar-coated nanomaterials exhibit strong interactions with several Escherichia coli strains. For example, the mannosylated nanoparticles bind strongly with E. coli ORN178, resulting in significant nanoparticles-mediated cell agglutination, while galactosylated nanoparticles and carbon nanotubes also bind strongly with pathogenic E. coli O157:H7. Potential applications of the cell adhesion with these sugar-coated nanomaterials are discussed.
Back to Nanoscale Materials: Synthesis, Application and Development I (General Session)
Back to The 56th Southeast Regional Meeting 2004 (November 10-13, 2004)