We describe a general concept for the use of liquid handling robotics in parallel synthesis and its implementation in hardware and software. The system allows rapid setup and execution of a variety of standard organic synthesis operations in array formats with minimal training. Such operations include liquid-liquid and solid phase extractions, filtrations, removal of aliquots for chemical analysis, spotting of TLC plates, transfers and reagent addition. The speed of setup and operation, coupled with ease of use, makes this approach amenable to use in a medicinal chemistry environment, either heavily or only occasionally, involved in parallel synthesis.
Back to Automation in the Chemical Lab-Analytical Methods-Environmental Chemistry (General Session)
Back to The 56th Southeast Regional Meeting 2004 (November 10-13, 2004)