Saturday, 13 November 2004: 8:10 AM-12:00 PM

Imperial I (Sheraton Imperial Hotel and Convention Center)

Medicinal Chemistry II (General Session)

Organizer:Charles A. Goss
Presider:Vassil I. Elitzin
8:10 AM Introductory Remarks
8:20 AM 575Novel aminophenyltetrahydronaphthalenes (APTs) as histamine H1 and serotonin 5HT2C ligands: Synthesis and GPCR signaling pharmacology
Ola M. Ghoneim, Jacqueline A. Legere, Raymond G. Booth
8:40 AM 576Utilizing Diverse Aromatic Structures to Block the ATP-Binding Site of Aminoglycoside Antibiotic Kinases
James Ricky Cox, Tera Rica Murdock, Christopher Sperry, Ahmad Al-Mestarihi
9:00 AM 577X-ray Structure of the R69D Phosphatidylinositol-Specific Phospholipase-C Enzyme: Insight into the Role of Calcium and Surrounding Amino Acids on Active Site Geometry and Catalysis
David Odanga Apiyo, Thomas L. Selby
9:20 AM 578Remote Hot-Spots Mediate Protein Substrate Recognition for Cdc25 Phosphatases
Jungsan Sohn, Kolbrn S Kristjansdottir, Alexias Safi, Benjamin R Parker, Brendan Kiburz, Johannes Rudolph
9:40 AM 579Essential Contribution of the C-Terminal Domain to the Structure of the Catalase-Peroxidase Active Site
Ruletha D. Baker, Carma O. Cook, Douglas C. Goodwin
10:00 AM 580Investigating Protein S-nitrosylation in Biological Systems
Matthew W. Foster, Jonathan S. Stamler
10:20 AM Break
10:40 AM 581Characterization of Metal Binding Sites in a Synthetic Phosphorylated α-Synuclein Peptide Fragment
Lucy L. Liu, Katherine J. Franz
11:00 AM 582Central Participation of an Interhelical Insertion in Catalase-Peroxidase Bifunctionality and Resistance to Peroxide-Dependent Inactivation
Yongjiang Li, Douglas C. Goodwin
11:20 AM 583Short Strong Hydrogen Bonds in Enzyme Catalysis
Pablo A. Molina
11:40 AM 584A Novel Bioinformatics Method for Determining Active Site Architecture and Specificity
Adam Powell, Thomas L. Selby

Back to The 56th Southeast Regional Meeting 2004 (November 10-13, 2004)