Surfactant is used in oral dosage forms as a solubilizer and/or wetting agent. Applications including liquid filled capsules, conventional dry tablets, and less conventional dry amorphous formulations employ surfactant for different purposes. This talk will discuss the impact of surfactant in these dosage forms, including (1) partial binary and ternary phase behavior of common pharmaceutical liquid filled capsule formulation components (corn oil, Polysorbate 80, fractionated mono-,di-, and triglycerides, water etc.), (2) the synergistic effect of a bile salt on microemulsification efficiency, and (3) the impact of surfactant during the dissolution and subsequent recrystallization of an insoluble drug in a conventional dosage form.