Interpenetrating networks of perfluoropolyethers (PFPE) and polyethyleneglycols (PEG) have been achieved to yield mechanically robust, optically transparent films over a wide range of compositions. Telechelic diols of these oligomers were transformed to a photocurable dimethacryloxy-form (DMA) and free radically cured at various composition ratios to yield free-standing films. Clear and colorless amphiphilic networks could be achieved when low molar mass versions of both the PFPE DMA (1 kg/mol) and the PEG DMA (550 g/mol) were used. Samples were characterized by a variety of techniques including dynamic mechanic thermal analysis (DMTA), which strongly suggests that a one phase material was achieved. By incorporating a threshold amount of PFPEs into PEG-based hydrogel networks, water swelling could be significantly reduced, which may offer a new strategy for a variety of medical device applications. Along these lines, strong inhibition of nonspecific protein adsorption was achieved with these amphiphilic network materials relative to an oligoethyleneglycol-based self-assembled monolayer (SAM) coated surface.