Advances in recent nanoscience technology have generated a new compilation of fluorescent biolabels derived from semiconductor quantum dots (QDs). Due to their properties of being water-soluble and biocompatible, these nanometer-sized probes prove to be beneficial. We report the molecular characterization of engineered bioconjugates comprised of highly luminescent dihydrolipoic acid (DHLA) capped cadmium selenide core/zinc sulfide shell, CdSe/ZnS, QDs attached to the native protein hen egg white lysozyme (HEWL) and/or its amylodiogenic analogue. We confirmed the bioconjugation by UV-vis and fluorescence spectroscopies, electrophoresis, transmission electron microscopy (TEM), and epifluorescence microscopy. This study allows us to present a simple method of protein-QD conjugation utilizing DHLA-capped QDs and characterize their optical properties. These bioconjugates could prove to be a potentially useful application in molecular biotechnology.