Recently, there has been much interest in engineering liposomes that can penetrate skin. It has been shown in several studies that the addition of small amounts of a detergent to conventional liposomes results in structures that seem to be able to penetrate through the stratum corneum and into the epidermis. The skin-penetrating ability has been attributed to an increase in flexibility of these liposomes, which presumably allows them to squeeze through small pores on the skin. However, the morphology and size distribution of liposomes have not been studied systematically as a function of detergent addition, and this provides the motivation for the present study. In this talk, we will show that the addition of detergents such as the non-ionic Tween 80 or the bile salt, sodium deoxycholate (SDC) can have profound and unexpected effects on the morphology of egg-phosphatidylcholine (egg-PC) liposomes. Specifically, in the case of egg-PC/SDC mixtures, we find that the addition of a moderate amount of SDC significantly narrows the size distribution of the liposomes. In other words, a polydisperse liposome population can be converted to one that is quite monodisperse upon detergent addition. We have studied changes in polydispersity using a variety of scattering techniques, including static and dynamic light scattering and small-angle neutron scattering (SANS). The spectra from SANS are especially interesting, with the appearance of multiple form factor peaks as the size distribution narrows.