Wednesday, 31 May 2006 - 3:50 PM Regency Ballroom D (Hyatt Regency Milwaukee) 61
Process Development of Gantacurium Chloride
Scott G. Van Ornum, Cedarburg Pharmaceuticals, Inc., Grafton, WI
Gantacurium Chloride is a rapid-onset, ultra-short acting non-depolarizing neuromuscular blocker for use as an adjunct to anesthesia to facilitate tracheal intubation and to maintain skeletal muscle relaxation during surgical procedures. The latest generation of neuromuscular blocking drugs aims to provide even greater advantages: as rapid an onset and offset as succinylcholine; disposition independent of organ function; and minimal adverse effects. The 16 step synthesis of Gantacurium Chloride will highlight the latest process development results and scale up effort.