Spirophenol is an optically active molecule that could potentially be used in the synthesis of liquid crystals. An improved synthetic route for this compound has been found, and methods of purification of the racemic mixture have been established. However, a liquid crystal sample must be enantiomerically pure in order to accurately determine its properties. A chromatographic chiral separation of spirophenol has been achieved, setting the stage for further exploration of the molecules that can be synthesized from it.