We have investigated the use of piperylene sulfone to couple separation and solvent and catalyst recycle with many reactions. As one example, we compare here its use for catalytic hydrogen transfer reactions with other organic solvents (DMSO, DMF, THF, acetone, toluene) and water. We reduced a series of aromatic ketones to their corresponding alcohols to demonstrate the stability to various functional groups. In all the cases, both a high conversion and enantiomeric excess were observed. The initial rate of the reduction reaction of acetophenone in piperylene sulfone was higher than in the organic solvents studied but lower than in water. This solvent was successful as an immobilization medium for catalyst recycle as well.