Wednesday, June 25, 2008
Congressional Room (Capital Hilton)
97

Chitosan Based Scaffolds by Lyophilization and Sc.CO2 Assisted Methods for Tissue Engineering Applications: A Benign Green Chemistry Approach

Kumari Rinki and Pradip Kumar Dutta. Motilal Nehru National Institute of Technology, Allahabad, Allahabad, India

Chitosan scaffolds with possible tissue engineering applications were synthesized and those treated under lyophilization and supercritical carbon dioxide (sc.CO2). 1% Chitosan solution in aq. acetic acid was treated with 37% formaldehyde solution; the resulting hydrogels were subjected to solvent-exchange before the final treatment procedures. Their morphology, pore structure, and physical properties were characterized by FTIR, NMR, thermal analysis, scanning electron microscopy, X-ray diffraction and porosimetry analysis. The sc.CO2 treated scaffolds showed much greater porosity and surface area in comparison to the lyophilized one. The lyophilized and sc.CO2 treated both kinds of scaffolds have antibacterial properties. The sc.CO2 assisted chitosan scaffold under green chemistry approach is highly pure and from hyegenic point of views it is an ideal material for biomedical applications.