Wednesday, June 25, 2008
Congressional Room (Capital Hilton)
98

Synthesis of Some New Bispyrrolidine Derivatives for Biological Interest

Amal Sabet Yanni, Assiut University, Assiut, 71516, Egypt

SYNTHESIS OF SOME NEW BISPYRROLIDINE DERIVATIVES FOR BIOLOGICAL INTEREST (PART IV)

Amal Sabet Yanni

Chemistry Department, Faculty of Science, Assiut University, Assiut 71526, Egypt

amalyanni@hotmail.com

Tel: 20123971342 (cell), 20882326189 (home), 20882411401 (work)

 

Representatives of this system belong to a class of biological active compounds and at the same time are excellent starting materials for developing a new type of biological active compounds.

Thermally induced crisscross1-5 cycloaddition of azines I and II (1 mole) in presence of 2,3-dichloro-1,4-naphthoquinone (2 moles) afforded the adduct III and IV respectively in one-pot reaction. The molecular structure of the products is reported and discussed. The processes for obtaining the title compounds reduce the use and generation of hazardous substances.

I,III a) R = -C6H5, b) R = -C6H4-p-OCH3, c) R = -C6H4-o-OH,

        d) R = -C6H4-p-Cl, e) R = -CH=CH-C6H5, f) R = -C4H3O

 

REFERENCES

[1]   Wagner-Jauregg, Ber., 63, 3224 (1930).

[2]   Van Alphen, Rec. Trav. Chem., 61, 892 (1942).

[3]   Amal Sabet Yanni, 16th International Conference on Physical Organic Chemistry, San Diego, CA, USA, August 4-9 (2002).

[4]   Amal Sabet Yanni, Polymer Networks 2004 Conference, Bethesda, Maryland, USA, August 15-19 (2004).

[5]   Amal Sabet Yanni, 10th Annual Green Chemistry Conference, Washington DC, USA, June 24-29 (2006).