Wednesday, June 25, 2008 Congressional Room (Capital Hilton) 102
New Method for α-Bromination of Ketones Using Br2 and β-Cyclodextrin in H2O
Seul Lee and Jong Chan Lee. Chung-Ang University, Seoul, South Korea
Direct conversion of carbonyl compounds into α-halocarbonyl compounds is very important synthetic transformation that has been received considerable attention. A mixture of aromatic or aliphatic ketones and bromine was heated and stirred in the presence of β-cyclodextrine in water. The monobromoketone was obtained exclusively within 1 hour at 60°C in high yields (70~90%). In this work, the reactions have been carried out without use of any toxic organic solvent and metal based catalyst and strong acid.