The 12 Principles of Green Chemistry are used to guide the development of a straightforward, yet thorough method to assess and compare analytical or chemical processes for their health and environmental impact. Similar assessments may neglect one or more of the major concepts in the 12 Principles. For example, a “green analytical profile” has been developed in concert with the National Environmental Methods Index database (www.nemi.gov) and neglects energy considerations. Our proposed assessment, rates analytical methods against waste amount and type, chemical health and environmental hazard, , and energy requirements. Reagents, procedures, and instrumentation are evaluated. Metrics were developed to calculate waste amount and energy use. During the calculation of waste, relative waste generated and sample size are considered. The energy-use metric assists in placing a value on the energy requirements of instrumental methods. The overall rating in each category can be easily fit into a visual presentation to allow for an at-a-glance comparison of several methods.