The Leuckart reaction is a unique one step method of reductive amination. It is a remarkably simple process that includes only two components: the carbonyl compound and formamide. The reaction is completed simply by heating the components at 160ºC to 185ºC for 6 to 25 hours. The long processing time seems to be the only shortcoming of the reaction. However, it is associated with a number of serious practical problems. First, the prolonged exposure of the reaction mixture to high temperatures inevitably leads to significant thermal decomposition of the components, and, consequently, to lower yields of the products and large amounts of waste. Second, maintaining high temperatures for a long period of time means high consumption of energy and increasing production costs which make the Leuckart reaction unattractive to the chemical industry. In this work a fast non-microwave procedure for the Leuckart reaction was developed. The new procedure can be completed in minutes instead of hours. It minimizes the use of heat and practically eliminates any thermal decomposition of the reaction mixture. The specific examples of the reactions will be presented. The project is supported by NIH grant P20 RR016741 from the NCRR.