Polythiols are known to be effective hardening agents for epoxy resins, providing access to low cure temperatures. Polythiols can also be used with isocyanates to produce polythiourethanes and as co-reactants for curing multi-olefinic compounds through thiol-ene chemistry. Novel polythiols derived from soybean oil have been developed by Chevron Phillips Specialty Chemicals and examined for their utility in coatings and adhesives applications. These polythiols offer the additional benefit of sustainability since they are derived from a natural source oil. It is instructive to compare the cradle-to-customer life cycle impacts of mercaptanized soybean oil (MSO) with commercial petroleum-derived polyether polyols and with available natural oil-based polyols. The presentation will include a discussion of the process scope, life cycle methodology and initial life cycle analysis of these products, summarizing various environmental impact factors and weighted BEES scores.