Direct Analysis in Real Time (DART) is a recently introduced sample introduction technique for mass spectroscopy which is performed in the open atmosphere and requires no sample preparation. When coupled with a high-resolution high-accuracy mass spectrometer, identification of the composition of mixtures is especially facile. This technology is often used for the analysis of finished products. The potential for Green Chemistry is in the identification of toxic or harmful reaction byproducts at low but significant levels EARLY in the synthetic process. Including this type of analysis at a time when scale-up and eventual production are still being designed, when it is cheaper and simpler to adjust reaction conditions and purification steps, allows for a more sustainable outcome.