A Green Engineering assessment of the pharmaceutical manufacturing process shows that solvents / waste solvents have the largest environmental footprint by far in natural resource usage, emissions of both toxic and GHG, and capital. The focus of this presentation that builds on this work will be on the opportunities presented in the recovery / reprocess / recycle and use of solvent waste streams. Models to calculate CO2 and Energy requirements for post treatment (WWTP, incineration, energy recovery) and approaches in recovering, reprocessing of combined solvent waste streams based on basic physical chemical properties will be reviewed. Implications / opportunities with RCRA / OSW (recycling of RCRA waste), FDA / CDER (process optimizations affected by FDA registrations), and DOC / NIST (3rd party markets for recovered solvents) will also be reviewed.