Imidazo[1,5-a]pyridines are a novel class of ligands that have gained recognition for its biological and medicinal applications. Recently, these ligands have been covalently incorporated into organic-inorganic hybrids as a means to remove heavy metal ions from water. Traditionally, the synthesis of imidazo[1,5-a]pyridines was limited to low yielding multi-step reactions, expensive and harsh reagents, and excessive reaction times. Here, we employ time and energy efficient microwave irradiation with milder reagents to synthesize a class of imidazo[1,5-a]pyridines. We hope to obtain higher yields and develop more environmentally friendly reaction conditions.