Tuesday, 24 May 2005
698

This presentation is part of: Organic Posters

Ligand-Free Palladium-Catalyzed Cyanation of Aryl Halides

Steven Weissman, Daniel Zewge, and Cheng Chen. Merck, Rahway, NJ

              A practical, ligand-free cyanation of aryl bromides that utilizes as little as 0.1 mol % Pd(OAc)2 in combination with a nontoxic cyanide source, M4[Fe(CN)6] (M = K, Na), is described.  The reactions are performed in DMAC at 120 oC and provide the corresponding aryl nitrile in 83-96% yield, typically in less than 5 h.  TON values of up to 7100 were attained.


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