Rapid analysis of intact proteins by LC/MS has become indispensable for target recombinant protein confirmation at various stages of drug discovery. The important issues here are assay speed (throughput), mass accuracy, ease of use, and open-access, etc. Over the past several years, we have developed strategies to achieve good balance among these aspects, using either short-gradient serial sample injection format or high throughput parallel approaches. The rationales, the details of the analytical platforms and their applications will be discussed.
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Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)