Tuesday, 24 May 2005 - 2:35 PM
590

This presentation is part of: Applications of LC-MS in Drug Discovery/Development

LC/MS Characterization of Intact Proteins: Open Access and High Throughput Applications

Bingbing Feng, GlaxoSmithKline, King of Prussia, PA

Rapid analysis of intact proteins by LC/MS has become indispensable for target recombinant protein confirmation at various stages of drug discovery. The important issues here are assay speed (throughput), mass accuracy, ease of use, and open-access, etc. Over the past several years, we have developed strategies to achieve good balance among these aspects, using either short-gradient serial sample injection format or high throughput parallel approaches. The rationales, the details of the analytical platforms and their applications will be discussed.

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