Tuesday, 24 May 2005 - 10:55 AM
486

This presentation is part of: Green Chemistry I

Maraviroc (UK-427,857) The Process chemists tale

Jens Ahman, Sarah J. Haycock-Lewandowski, Nicola Mawby, Alex Wilder, and Steve Challenger. Pfizer, Sandwich, United Kingdom

This talk will detail the development of an environmentally friendly synthesis of CCR-5 receptor antagonist UK-427,857 from the medicinal chemistry route through a bulk enabling route to a route operating in a commercial production plant. The use of Green-Chemistry metrics to guide process development towards a more environmentally friendly synthesis will be detailed

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