Cyclopropylamines and substituted cycloproylamines are important structural element s in a variety of biologically active compounds. We have previously reported the Ti(II) mediated intramolecular coupling of a terminal olefin and the N,N-dimethyl carboxamide moiety of aromatic amino acid derivatives in the synthesis of novel and strained bicyclic structures. Here, we present the extension to other amino acids, [4.1.0] bicycles, and different amino substitutions. We also report the attempts of ring expansion to obtain novel piperidines and azepanes.
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Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)