Tuesday, 24 May 2005

This presentation is part of: Polymeric Biomaterials Posters

Using Supercritical CO2 for polymer/drug formation into microspheres

Princy Varughese, Ke Wu, and Jing Li. Rutgers,The State University of New Jersey, Piscataway, NJ

Supercritical CO2 (sc-CO2) has been used for extraction and separation (e.g decaffeination), as a reaction medium (for polymerization) and as a reprocessing fluid (in production of foams). Recent interest has sparked in using supercritical CO2 as an anti-solvent for particle formulation. Here, drug-loaded polymers are dissolved in an organic solution and are introduced through a nozzle to the sc-CO2. By an anti-solvent process, the sc-CO2 extracts the solvent and the drug-loaded polymers saturate out, solvent free, into the desired shapes and sizes. These processed drug-loaded polymers would lead to improved drug delivery systems with enhanced therapeutic effects in terms of less dosage and controlled release of the drug. Here, we report some preliminary results on selected materials. The processed particles have been characterized by SEM and DSC for morphology and thermal properties, respectively

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