Tuesday, 24 May 2005

This presentation is part of: Organic Posters

Highly Efficient Synthesis of b-Amino Acid Derivatives via Asymmetric Hydrogenation of Unprotected Enamines

Yi Hsiao1, Nelo R. Rivera1, Thorsten Rosner1, Shane W. Krska1, Eugenia Njolito1, Fang Wang1, Yongkui Sun1, Joseph D. Armstrong III1, Edward J. J. Grabowski1, Richard D. Tillyer1, Felix Spindler2, and Christophe Malan2. (1) Merck Research Laboratories, Rahway, NJ, (2) Solvias

A direct asymmetric hydrogenation of unprotected enamino esters and amides is described. Catalyzed by Rh complexes with Josiphos type chiral ligands, this method gives b-amino esters and amides in high yield and high ee (9397 %ee). No acyl protection/deprotection is required.


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