Phenolic derivatives present in olive oil have excellent antioxidant activity and play an important role in preventing cardiovascular disease and immune dysfunction. In addition, their antioxidant activity may be useful for regeneration of oxygen-damaged skin cells. Three phenolic compounds, vanillic acid, syringic acid, and 3-methoxysalicylic acid have been successfully incorporated into poly(anhydride-esters) using melt condensation polymerization methods. The advantages of a polymeric function are easy fabrication of films, fibers, and micropsheres for applications in various fields as additives in drugs or cosmetics. Moreover, toxicity or side effects will be minimized by reducing and controlling the antioxidant release. Polymer properties such as molecular weight, thermal transitions, solubility, hydrophobicity, and polymer erosion rates are attributed to the methoxy groups. For example, more methoxy-substituted polymers (i.e., syringic acid) have more hydrophilic values, based on contact angle measurements and diacid solubility in PBS than less methoxy-substituted polymers, which is also consistent with their slower erosion rates. Their biological activity will be evaluated for topical applications by cytotoxicity tests using fibroblast cells.
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