Tuesday, 24 May 2005

This presentation is part of: NanoScience and Technology Posters

Functionalized Polyaniline/Carbon Nanotube Composite for Sensitive Detection of Glucose by a Non-Enzymatic Approach

Yufeng Ma, Ali Shah, and Huixin He. Rutgers University, Newark, NJ

The ability to detect trace level of glucose not only allows for early diagnosis of diabetes, it also dramatically reduces the blood volume needed for regular monitoring of diabetic patients.

Although the development of glucose sensors for use in battling diabetes has been the focus of intense research since the 1960's, most advanced sensors are based on the enzyme glucose oxidase (GOx) coupled to electrochemical systems, and the sensitivity is still in the millimolar range. In this presentation we will report a non-enzymatic approach to detect glucose, the concentration as low as 1 nM can be detected by modifying the gold electrode with a thin layer of poly (aniline boronic acid) /carbon nanotube composite. Glucose chemically binds to the boronic acid groups, which greatly influences the electrochemical activity of the polyaniline backbone due to steric effects. The carbon nanotubes in the composite not only increase the effective electrode surface area (thereby increasing the density of boronic acid groups for glucose binding), they also greatly increase the stability of the film. Glucose concentrations as low as 1 nM was detected with cyclic voltammetry, and the electrochemical current decreased as the concentration of glucose increased from 1 nM to 10 nM, and leveled off in higher concentrations for some films. The sensitivity is four orders of magnitude greater than the current glucose sensors. It holds great potential for early diagnosis of diabetes, and it could also dramatically reduce the pain of diabetic patients by reducing the blood volume needed for regular monitoring.

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