Tuesday, 24 May 2005 - 1:35 PM

This presentation is part of: Applications of LC-MS in Drug Discovery/Development

Overview of LC/MS in Drug Discovery and Development

Birendra N. Pramanik, Schering-Plough Research Institute, Kenilworth, NJ

With advancement in ionization methods, liquid chromatography / mass spectrometry (LC/MS) has emerged as a powerful technology for the characterization of pharmaceuticals. This presentation will give an overview of LC/MS in drug discovery and development process, emphasizing problem solving skills in utilizing LC/MS and LC/MS/MS with examples from pharmaceutical research. They include structural analysis of trace-level impurities in drug substances, microwave-assisted MS analysis for proteins/peptides, and application to proteomics.

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