Monday, 23 May 2005 - 10:40 AM

This presentation is part of: Bioinformatics

Phenotype Mapping of Genes

Qing Zhang, Schering Plough Research Institute, Kenilworth, NJ

Annotated genomes of human and rodents provide an unprecedented opportunity for mining drug targets for diseases, especially when combined with disease-susceptible loci (chromosome regions that carry disease-susceptible genes) obtained from traditional genetics studies. While databases such as Online Mendelian Inheritance in Man (OMIM), Mouse Genome Informatics (MGI), and Rat Genome Database (RGD) provide query tools to search for disease-susceptible loci in human, mouse or rat, direct cross-species comparison is not available from these sites and nor are druggable genes highlighted.

A phenotype mapping tool has been developed in-house that provides easy access to druggable genes (such as GPCRs and protein kinases) in human and their rodent homologs, chromosome location of these genes, and if there are disease-related loci in the chromosome region these genes reside in. Strain-specific mouse SNP data have also been integrated so that users can quickly find out if SNPs exist between the two strains used in genetics study that characterized the disease-susceptable locus. The tool is equipped with search capabilities for gene, phenotype or chromosome region. Examples of using this tool to compile drug target candidates will also be presented.

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