Tuesday, 24 May 2005 - 9:30 AM
408

This presentation is part of: Stars, Branched, Graft and Dendritic Polymers

Preparation of Biocompatible and Biodegradable Nanobrushes from Cellulose and Hydroxyapatite Nanocrystals

Ivan Gitsov, SUNY College of Environmental Science and Forestry, Syracuse, NY, Anne Kathrine Overgaard, Technical University of Denmark, Kgs. Lyngby, Denmark, and Bhushan Hole, Syracuse University, Syracuse, NY.

The main goal of this study was the preparation of biocompatible and biodegradable nanobrushes as composite ingredients and reactive precursors for reinforced hydrogels. The nanobrushes were formed from cellulose and hydroxyapatite nanoparticles via ring-opening polymerization of dl-lactide and stannous octoate as the catalyst. The effect of the polymerization conditions (time, monomer feed ratio, temperature and solvent) on the yield, grafting density and polymer chain length of the hybrid particles was investigated by FT-IR spectroscopy, NMR and chromatographic techniques. It was found that the yields of the polymer hybrids varied from 11 % to 64 % for the cellulose and from 12 % to 87 % for the hydroxyapatite depending on the reaction conditions. The formation of long or relatively short poly(lactide) chains was also affected by the polymerization conditions as revealed by FT-IR analyses and differential scanning calorimetry. The thermal properties of the nanobrushes were investigated by thermal gravimetric analysis, as well.

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