Tuesday, 24 May 2005
723

This presentation is part of: Organic Posters

Sythesis and Characterization of a Naphthoquinone Derived Amino Acid

Bruce R. Lichtenstein1, Ronald L. Koder2, and P. Leslie Dutton2. (1) University of Pennsylvania, Philadelphia, PA, (2) The Johnson Foundation and the University of Pennsylvania, Philadelphia, PA

Studies on quinone oxidoreduction have heretofore been almost exclusively performed within quinoproteins; thus limiting the experimental contexts to what nature designed. As an alternative to natural proteins, the use of an architecturally diverse synthetic-protein scaffold, or maquette, would allow for a much more tailored approach towards exploring quinone electron chemistry. Towards that end, we report the synthesis of a naphthoquinone-derived amino acid, its integration into a synthetic peptide, and initial explorations of its oxidoreduction properties.

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