The formation of peritoneal (intra-abdominal) adhesions is a common and dangerous side effect of general abdominal surgery, hernia repair, and radiation therapy, as well as many other invasive abdominal procedures. These adhesions may result in chronic pelvic pain, infertility and hemorrhaging. To reduce the occurrence of these internal adhesions, the use of barrier polymers is becoming a more frequent and very successful solution. One such polymer is Sodium Carboxymethylcellulose (SCMC) (fig. 1), which is a very attractive candidate for nucleophilic drug substitutions due to the presence of the carboxymethyl residues. In this study, we monitor the release of chemotherapy agents, specifically Mitoguazone and Eflornithine (fig. 1), from the polymer-drug conjugate previously synthesized.
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