Psymberin is a pederin like natural product isolated from marine sponge by Crews and coworkers. It showed potent cytotoxicity and high selectivity against several solid tumor cell lines. A convergent and stereoselective synthesis of psymberin, which involves the use of a spirodiepoxide as a key intermediate, is underway. Progress toward the total synthesis of this interesting molecule will be presented.
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Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)