Tuesday, 24 May 2005

This presentation is part of: Graduate Posters

Synthesis and Novel Homolagation Reactions of 1,2-Cyclopropanated Carbohydrates

Cecilia H. Marzabadi and Jamie Talisman. Seton Hall University, South Orange, NJ

The goal of the research is to incorporate cyclopropanated carbohydrate elements into drug-like molecules for the treatment of epilepsy and depression. Towards this end, homologation reactions of 7,7-dihalo-1,2-cyclopropanated carbohydrates are being explored. In particular, generation of reactive carbenoids via lithium-halogen exchange followed by an electrophilic quench is of interest. Also, we are pursuing carbohydrate analogues of biologically-active examples in the literature that contain cyclopropane and tetrahydropyran moieties. Thus, carbohydrate derivatives of 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate, an agonist for the metabotropic glutamate receptor, are current synthetic targets.

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