Tuesday, 24 May 2005
739

This presentation is part of: Polymeric Biomaterials Posters

Amphiphilic Star-like Macromolecules for targeted drug delivery

yichao Zhang, Rutgers University, Piscataway, NJ

Unimolecular micelles are multi-branched polymers that solubilize hydrophobic drug molecules in aqueous environment. These polymers were designed with multi-branched, hydrophobic interior (core) and hydrophilic exterior (shell) to maintain physical properties characteristic of conventional micelles, but with enhanced thermodynamic stability. In effort to utilize unimolecular micelles to transport and deliver anti-cancer drugs, we are developing a series of Amphiphilic Star-like Macromolecules (ASM) with improved drug loading efficiency. The hydrophobic core is prepared by acylation of tetra branched core initiator with various mucic acid derivatives. The hydrophilic shell is assembled by conjugating poly(ethylene glycol) (PEG) chains to the core. Targeting moieties, such as folic acid, are introduced at the PEG chain end to aid in selective delivery of encapsulated drugs.

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