The purpose of this research project is to make nucleosides, to be used as potential antibiotics or anticancer drugs. Since the chemistry of carbohydrates is pertinent to the process of cell recognition and regulation of cell growth, developing novel nucleosides may result in enhanced binding and interaction with cellular targets. Our proposal is to use a variation of protecting groups at the C-2' position of the sugar Thymine and Adenine for the nucleosides. These molecules will then be tested for anti-tumor or antibiotic properties.
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