A2E, a pyridinium pigment with two retinoid side chains, is an ocular pigment involved in AMD, the leading cause of blindness of person over age 55 in USA and Europe and for which no remedy exists. In addition to A2E several other A2E analogs have been characterized from the eye. Photooxidation of A2E with blue light (430 nm) gives rise to an unprecedented nona-oxo. In addition to this nona-oxo A2E , blue light irradiation gives rise to a complex mixture of oxidation products, some of which may damage the cell. The (S) and (R) isomers of all-trans retinal dimer have also been isolated from human eyes. The genesis, interrelations of these pigments and preparation of antibodies will be discussed. The constituents of bilberry that have beneficial effects on AMD will also be presented.
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Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)