Tuesday, 24 May 2005

This presentation is part of: Graduate Posters

Synthesis and NO-related Properties of Cycloadducts of C-Nitroso Compounds

Harinath Chakrapani and Eric J. Toone. Duke University, Durham, NC

Nitric oxide is a ubiquitous signaling molecule that has been identified to be involved in a plethora of biological processes including regulation of smooth muscle relaxation, inhibition of platelet activation, stimulation of immune response against bacterial pathogens and tumor cells, neurotransmission, and control of gene regulation. Despite the widespread medical use of several NO donors, selective and controlled delivery of NO is still a major research focus area. C-nitroso compounds (CNOs) with one or more geminal electron acceptors are good exogenous nitric oxide donors. CNOs reversibly form Diels-Alder adducts and the position of the equilibrium depends on the nature of the diene. In an attempt to regulate the rate of NO release, we synthesize and study the NO-related properties of cycloadducts of CNOs.



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