Monday, 23 May 2005: 9:00 AM-12:00 PM

Room 203 (Science & Engineering Resource Center)

Medicinal Chemistry (MEDI)

Kinase / Virtual Screening

This session provides an overview of medicinal chemistry research efforts targeting kinases for therapeutic application. Virtual screening and docking analysis will be discussed where relevant.
Organizer:Robert Goodnow Jr.
Presiders:Dorothy Kominos
Paul Cox
9:00 AM Dorothy Kominos & Paul Cox
9:05 AM Development of Aniline amides Containing Alternative Cores as Orally Active P38 MAP kinase Inhibitors
Katerina Leftheris, John Hynes, Jr., Alaric Dyckman, Tianle Li, Shuqun Lin, Stephen T. Wrobleski, Hong Wu, Rosemary Zhang, Kathleen M. Gillooly, Derek Loo, Kim W. McIntyre, Sidney Pitt, Ding Ren Shen, David J Shuster, Arthur Doweyko, John Sack, Joel Barrish, John Dodd, Gary L. Schieven
9:35 AM Inhibitors of mitogen-activated protein (MAP) kinases synthesized by parallel solution- and solid-phase methods
Jeremy Green
10:05 AM Design, Synthesis and SAR of Pyrimidopyrimidines, Dual KDR/FGFR TyrosineKinase Inhibitors
Pamela Rossman
10:35 AM Coffee Break
11:00 AM Discovery of BMS-354825, a dual Src/Abl kinase inhibitor with potent anti-tumor activity in preclinical assays
Louis J. Lombardo, Francis Y. Lee, Ping Chen, Derek Norris, Joel C. Barrish, Kamelia Behnia, Amy Camuso, Stephen Castaneda, Lyndon A. M. Cornelius, Jag Das, Arthur M. Doweyko, Krista Fager, Christine Flefleh, Craig Fairchild, John T. Hunt, Ivan Inigo, Kathy A. Johnston, Amrita Kamath, David Kan, Herbert Klei, Roger Luo, Punit Marathe, Suhong Pang, Russell Peterson, Sidney Pitt, Gary L. Schieven, Robert J. Schmidt, John Tokarski, Mei-Li Wen, Robert Wild, John Wityak, Robert M. Borzilleri
11:30 AM Discovery of novel p38 MAP kinase inhibitors:
Gulzar Ahmed

Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)