Tuesday, 24 May 2005: 9:00 AM-12:00 PM

Room 203 (Science & Engineering Resource Center)

Medicinal Chemistry (MEDI)

Ion Channel

Ion Channels in Drug Discovery: Exciting New Targets and Exciting New Drugs Although, Ion Channels are well-established targets for drug intervention, the last several years have seen resurgence of the interest of Ion Channels as targets for Drug Discovery. Concurrent advances in Genomics and Structural Biology have kindled this regeneration of interest. Further advances in Natural Products Chemistry and the Synthetic Organic Toolbox have made what once would have been considered daunting synthetic targets into interesting drug leads. This session will feature New Ion Channels Targets for Therapies, New Therapies for Under-treated Diseases, New Modeling Techniques for Optimizing Ion Channel Modulators and New Modulators Derived from Natural Sources.
Organizer:Robert Goodnow
Presider:Thomas J. Caufield
9:00 AM Introductory Remarks Thomas Caulfield
9:05 AM Blocking Ion Channel KCNN4 Alleviates the Symptoms of Experimental Autoimmune Encephalomyelitis in Mice
Chuan-Chu Chou, Eva-Pia Reich, Long Cui, Lily Yang, Catherine Pugliese-Sivo, Andrei Golovko, Mary Petro, Galya Vassileva, Inhou Chu, Amin A. Nomeir, Li-Kang Zhang, Xian Liang, Joseph A. Kozlowski, Satwant K. Narula, Paul J. Zavodny
9:40 AM Ion Channel Modulation: Can it Enhance Neurotransmission, Conduction, and Myelination for New Therapeutic Interventions?
Craig P. Smith
10:10 AM Coffee Break
10:25 AM De novo design of potent T-type calcium channel blockers
Daniel L. Cheney, Jon Hangeland, Todd Friends, Paul Levesque
11:10 AM Identification of Ion Channel Modulators
Maria L. Garcia

Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)