Monday, 23 May 2005: 9:00 AM-12:45 PM

Room 202 (Science & Engineering Resource Center)

Biological Chemistry (BIOL)

DNA Gadgets: Making Novel Use of the Physico-chemical Properties of DNA

The double helical structure and interactions, which are key to the preservation and expression of the genetic code, provide the underlying basis for an increasing number of novel, rationally designed, DNA “gadgets”. The sequence of base side groups along a series polynucleotide chains defines the pattern and the classical Watson-Crick pairing of complementary bases in a variety of branched backbone motifs constitutes the mechanism for weaving long molecular threads into elaborate spatial networks. Judicious molecular design allows for the exchange of double helical pairing partners and the concomitant construction of junctions which are reminiscent of the multi-armed helical forms produced in the biochemical copying and editing of the genetic code. Other design elements take advantage of the sequence-dependent conformational sensitivity of the double helix to changes in the local ionic environment, allowing selected parts of the assembly to undergo changes of helical state or topology and thereby to impose new constraints of twisting and/or extension on the remainder of the system. Thus, nanoscale objects, lattices and nanomechanical devices can be built and tuned with great precision. Presentations in the symposium will focus on the principles that underlie the atomic control of synthetic DNA assemblies and illustrate applications of these principles in state-of-the-arts constructs for molecular robotics and engineering.
Organizers:Nadrian C. Seeman
Wilma K. Olson
Presider:Wilma K. Olson
9:00 AM DNA: Not Merely the Secret of Life
Nadrian C. Seeman, Shiping Liao, Baoquan Ding, William B. Sherman, Tong Wang, Pamela E. Constantinou, Jens Kopatsch, Ruojie Sha, Philip S. Lukeman
9:35 AM DNA Machines
Chengde Mao, Yi Chen, Ye Tian, Seung-Hyun Lee
10:10 AM Engineering DNA Motors and Sensors
Niles A. Pierce
10:45 AM Nucleation and Stability of Nanotubes from DNA Tiles
Ashish Kumar, Axel Ekani-Nkodo*, Armand Vartanian, Deborah K. Fygenson
11:20 AM DNA-crosslinked gels
Bernard Yurke, David C. Lin, Noshir A. Langrana
11:55 AM DNA as the Raw Material for General-purpose Electrical Biosensors
Dipankar Sen, Richard Fahlman, Carlo Sankar, Edward Leung

Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)