Monday, 5 June 2006: 8:30 AM-12:00 PM
Cocoa 4 (Hershey Lodge and Convention Center)
Analytical Chemistry (ANYL)
LC-MS in Drug Metabolism
Mass spectrometry, and in particular HPLC-MS/MS, has become an indispensable tool for the study of drug metabolism and pharmacokinetics in the pharmaceutical industry. In drug discovery and early development, increasing throughput for quantitative analysis is an ongoing challenge, as is generating increasingly detailed metabolic pathways from both in vitro and in vivo systems. This session will explore the impact that recent advances in automation technologies and in mass spectrometer design have had in this arena, with presentations that reflect the substantial increases in information content available for qualitative characterization of metabolic pathways, and the greatly increased capacity for generating high quality quantitative data.
Sponsor: Merck & Co., Inc
Organizer:James Yergey
Presider:James Yergey
8:30 AM131Use of In-line electrochemical systems for metabolite synthesis and assisted ionization with LC-MS in drug metabolism studies
Darwin Asa
8:50 AM132Low volume parallel liquid chromatography with MS capability: enabling high throughput determinations
Sergio Guazzotti, Sheila Bilbao
9:10 AM133Integrated bioanalytical support from early discovery through clinical development
Timothy Olah
9:45 AM Break
10:05 AM134Strategies for increasing throughput in drug discovery PK assays
Kimberly W. Dunn-Meynell, Cymbelene Nardo, Sam Wainhaus, Walter A. Korfmacher
10:40 AM135Using the hybrid QqQ – LIT technology in drug metabolism to gather more information from each analysis
Carmen L. Fernandez-Metzler, Christine Dieckhaus, Richard W. Gundersdorf, Richard C. King
11:15 AM136High speed analysis with MALDI
Thomas R. Covey

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