| Monday, 5 June 2006: 1:30 PM-5:00 PM | |||
| Crystal A (Hershey Lodge and Convention Center) | |||
| Biological Chemistry (BIOC) | |||
| Protein and Peptide Modifications in Biomarker Development | |||
| Covalent protein modifications produced by reactive endogenous metabolites, drugs or environmental pollutants associated with disease are active research areas in chemical toxicology. Research progress has been accelerated by greater access to mass spectrometric instrumentation, the emergence of high throughput differential protein display technologies and bioinformatics tools that enable the sensitive and specific detection of modified proteins. In light of data emerging from adduct studies using these toxicoproteomic technologies, a major scientific challenge is to determine the mechanistic relevance of protein adducts to disease. Although adducts can serve as biomarkers of exposure, effect or susceptibility and provide clues about the underlying mechanisms of modified protein action, some may be unrelated to disease endpoints. Arrival at a more complete understanding of the biological significance of protein adducts requires the multidisciplinary participation of the chemistry, toxicology, bioinformatics, mass spectrometry, clinical research and other research communities. The half-day session “Protein and Peptide Modifications in Biomarker Development” will provide an overview of toxicoproteomics and present research on the roles of protein adducts in neurodegenerative, cardiovascular and liver diseases. Contributed poster submissions are sought to stimulate and continue an interdisciplinary dialogue, using the chemistry of protein adducts as a focal point, for understanding fundamental biological processes that operate in both good health and disease states. | |||
| Sponsor: | ACS Division of Biological Chemistry, ThermoElectron, Ciphergen, Bioanalytical Systems Inc., Applied Biosystems - Sciex, and Merck | ||
| Organizer: | Peter Scholl | ||
| Presider: | Peter Scholl | ||
| 1:30 PM | Welcoming Remarks | ||
| 1:40 PM | 252 | Toxicoproteomics: The application of proteomics to toxicology B. Alex Merrick | |
| 2:20 PM | 253 | Bioactivation of selective estrogen receptor modulators to reactive quinoids: Identification of protein targets Judy L. Bolton | |
| 3:00 PM | 254 | Oxidative stress-mediated formation of protein and peptide adducts Ian A. Blair, Tomoyuki Oe, Clementina Mesaros, Koichi Inoue, Seon Hwa Lee, Carlos Garner, Bradley L. Ackermann | |
| 3:40 PM | 255 | Nitric oxide mediated post-translational protein modifications Harry Ischiropoulos | |
| 4:20 PM | 256 | Proteomic identification of potential susceptibility factors in drug-induced liver disease Kevin D. Welch | |
| 5:00 PM | Break | ||
Back to The 38th Middle Atlantic Regional Meeting (June 4-7, 2006)