ABSTRACT: A colorimetric diffusion-reflection imaging (CDRI) high throughput analytical technology was developed for library analysis. In the investigation, quartz sands were employed as light diffusion-reflection media. Inorganic and organic Compounds having characteristic absorption bands in visible light could be quantified by this method with relative analysis errors within ±6%. In the current investigation, compounds, such as CrCl3, KMnO4, methylene blue, and acrolein were employed as substrates and the UV spectrometer and traditional GC (with thermal conductivity detector) were employed to check the reliability of our CDRI technology. The current technology is capable of analyzing more then 100 samples simultaneously.