Quantum-dot fluorescence intermittency or "blinking," in which individual dots cycle between on (bright) and off (dark) states over time scales ranging from milliseconds to minutes, is of great fundamental and practical interest. The mechanism(s) of blinking and methods for controlling blinking in 3D-confined quantum dots are under active investigation. One may wonder if 2D-confined quantum wires also exhibit fluorescence intermittency, and if so how the extended dimension in wires will influence blinking behavior. We are studying blinking in CdSe quantum wires by single-wire imaging and spectroscopy. We have found that most wires exhibit a "twinkling" phenomenon, in which the fluorescence intensity in small, localized wire domains fluctuates independently of similar fluctuations in nearby domains. However, a persistent fraction of the wires exhibits synchronous blinking over large wire segments (lengths > 500 nm), or even over whole wires (lengths > 2 μm). Significantly, the blinking dynamics follow inverse-power-law statistics comparable to previous findings for quantum dots, suggesting mechanistic similarities between dot and wire blinking. A new mechanism for blinking will be proposed that is based on photochemical filling of surface trap states, which is consistent with quantum-dot and wire behavior. The new mechanism is supported by theoretical simulations, which will also be presented.