William M. Sherrill and Michael Rubin. University of Kansas, Lawrence, KS
A modular approach to novel cyclopropane-containing C1-symmetric chiral aminophosphine ligands has been developed. This strategy permits easy installation of different N- and P-containing substituents in the side chain of cyclopropane with complete control of all chiral centers in the cyclopropyl backbone. Cyclopropylaminophosphine ligands with both cis- and trans- relative orientations of the amino and the phosphino moieties can be obtained with similar efficiency from easily available cyclopropylcarboxylates. Expeditious syntheses of exemplary chiral aminophosphine ligands will be demonstrated. Benefits of the employment of the novel ligands in transition metal catalysis in CO2-expanded solvents will be discussed.
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