The synthesis and diversification of a library of flavone scaffolds using oligomeric alkyl cyclohexylcarbodiimide (OACC) is reported. Scaffolds with potential as cyclin-dependent kinase inhibitors were targeted. Flavones have demonstrated antiprolific activity and are novel anti-cancer agents with possible selective cytotoxicity. Synthesis of 6- and 8-amino substituted scaffolds capable of coupling with a carboxcylic acid was performed. Amination of carboxcylic acids with flavone scaffolds was performed using OACC as a coupling reagent in a homogenous solution and polystyrene-bound carbonate as a scavenger. The use of SPOC bypassed the need for chromatography and yielded products through simple filtration in good purity and high yields.