Catalytic use of o-iodoxybenzoic acid (IBX) in presence of Oxone as a co-oxidant is demonstrated for the oxidation of primary and secondary alcohols in user and eco-friendly solvent mixtures. Also demonstrated is the in situ (re)oxidation of 2-iodosobenzoic acid (IBA) and even commercially available 2-iodobenzoic acid by Oxone to IBX allowing one to use these less hazardous reagents, in place of potentially explosive IBX, as catalytic oxidant. Oxidation of variety of alcohols using the new catalytic procedure is carried out to yield the corresponding carbonyl compounds in excellent yields. Salient features of the new protocol and compatibility of other functional groups during the oxidation reaction will be discussed.
Back to Organic Chemistry Session I
Back to The 33rd Northeast Regional Meeting (July 14-17, 2005)