In this talk we will present our efforts in two key areas in the discovery and selective growth of pharmaceutical polymorphs. Crystallization, in general, occurs through heterogeneous nucleation; we use self-assembled monolayers (SAMs) to study the effect of synthetic surfaces on the selective heterogeneous nucleation of polymorphs. In the first area, we will discuss our onboard approaches to the synthesis of thiol and silane SAMs and their application in the selective growth of polymorphs of organics (benzamide), inorganics (KNO3), and pharmaceutical compounds (carbamazepine). In the second area, we will address our efforts in the creation of multi-component cocrystals. Pharmaceutical cocrystals can be thought of as new forms of drugs, with a potential to have improved bioavailability and other properties. We will present simple strategies for the creation of binary and ternary supramolecular complexes using hydrogen bonding synthons and discuss how these strategies may be extended to potential pharmaceutical targets.
Back to Symposia: Surface Chemistry
Back to The 33rd Northeast Regional Meeting (July 14-17, 2005)